Author

R. N. Bone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

C. Evans-Molina· 3 shared P. Krishnan· 3 shared S. A. Weaver· 2 shared T. M. Kono· 2 shared X. Tong· 2 shared C. Muralidharan· 1 shared C.-C. Lee· 1 shared D. Singhal· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPhysiology

C. Evans-Molina

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Author profile →

3 papers

Recent·Most cited

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell

H. Iida, T. M. Kono, C.-C. Lee, P. Krishnan, M. C. Arvin, S. A. Weaver, T. S. Jarvela, R. N. Bone, X. Tong, P. Arvan, I. Lindberg, C. Evans-Molina

This study identifies SERCA2 as a regulator of proinsulin processing and processing enzyme maturation in pancreatic β cells, linking ER Ca2+ levels to impaired glucose tolerance in diabetes.

bioRxiv · Jun 13, 2022 · PreprintPhysiology

A discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

F. Syed, D. Singhal, K. Raedschelders, P. Krishnan, R. N. Bone, M. R. McLaughlin, J. E. Van Eyk, R. G. Mirmira, M.-L. Yang, M. J. Mamula, H. Wu, X. Liu, C. Evans-Molina

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

bioRxiv · Dec 22, 2021 · PreprintPhysiology

Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet

R. N. Bone, X. Tong, S. A. Weaver, C. Muralidharan, P. Krishnan, T. M. Kono, C. Evans-Molina

This study shows that loss of SPCA1 in pancreatic beta cells reduces Golgi Ca2+ levels, impairs glucose-stimulated insulin secretion, and decreases autophagy.

bioRxiv · Aug 30, 2021 · PreprintCell Biology