X. Tong

The Building Blocks of Early Land Plants: Glycosyltransferases and Cell Wall Architecture in the model liverwort Marchantia polymorpha

This study analyzes cell wall glycans and glycosyltransferases in the liverwort Marchantia polymorpha, revealing unique features and developing a resource for genetic studies.

Modulation of the GT Family 47 clade B gene affects arabinan deposition in elaters of Marchantia polymorpha

This paper investigates the role of GT47B genes in arabinan deposition in Marchantia polymorpha by analyzing mutants and overexpression lines, revealing reduced 1,5-L-arabinan in Mparadl2 mutants and challenges in purifying GT47B proteins.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in Macaques

This study identifies compartment-specific antibody correlates of protection against SARS-CoV-2 Omicron in macaques, showing neutralizing antibodies in serum and antibody-dependent cellular phagocytosis in bronchiolar lavage are strongest correlates.

Data-driven system matrix manipulation enabling fast functional imaging and intra-image nonrigid motion correction in tomography

This paper introduces methods to improve tomographic imaging by compressing system matrices and correcting motion artifacts, demonstrating improvements in 3D photoacoustic computed tomography.

Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses

This study compares antibody responses to COVID-19 and influenza vaccines given together versus separately, finding higher and more durable Spike-specific IgG1 responses with concurrent administration.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

Leptomeningeal anti-tumor immunity follows unique signaling principles

The paper investigates IFN-γ signaling in leptomeningeal metastasis and shows its role in recruiting myeloid cells to control tumor growth.

Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAFV600E-induced cellular senescence in human melanocytes

The paper shows that loss of desmoglein 1 in keratinocytes reduces senescence in BRAFV600E-expressing melanocytes by promoting NTN4 expression.

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

Waning and boosting of functional humoral immunity to SARS-CoV-2

This study compares the waning and boosting of functional humoral immunity induced by CoronaVac and BNT162b2 vaccines, showing differences in kinetics and boosting efficacy.

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell

This study identifies SERCA2 as a regulator of proinsulin processing and processing enzyme maturation in pancreatic β cells, linking ER Ca2+ levels to impaired glucose tolerance in diabetes.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Detecting Phytophthora cinnamomi associated with dieback disease on Carya cathayensis using loop-mediated isothermal amplification

The paper detects Phytophthora cinnamomi in Carya cathayensis using loop-mediated isothermal amplification and confirms its association with dieback disease.

Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet

This study shows that loss of SPCA1 in pancreatic beta cells reduces Golgi Ca2+ levels, impairs glucose-stimulated insulin secretion, and decreases autophagy.

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changes

This study shows that lipid droplets protect human β cells from lipotoxic stress by maintaining FFA homeostasis and preserving β cell identity.

First record of a mermithid nematode (Nematoda: Mermithidae) parasitizing winged females of gall-forming aphids (Hemiptera: Aphididae: Eriosomatinae)

The paper reports the first record of a mermithid nematode parasitizing winged females of eriosomatine aphids and describes its phylogenetic relationship and impact on host reproduction.

The essential transcriptional regulator HDP1 drives expansion of the inner membrane complex during early sexual differentiation of malaria parasites.

This study identifies HDP1 as a transcriptional regulator essential for upregulating inner membrane complex genes during early gametocytogenesis in Plasmodium falciparum.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

Stapled peptides based on Human Angiotensin-Converting Enzyme 2 (ACE2) potently inhibit SARS-CoV-2 infection in vitro

This study designs stapled peptides based on the ACE2 helix to inhibit SARS-CoV-2 infection, showing potent antiviral activity with no cytotoxicity.

Personalized vagino-cervical microbiome dynamics after oral probiotics

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

Simple Behavioral Analysis (SimBA): an open source toolkit for computer classification of complex social behaviors in experimental animals

SimBA provides an open-source toolkit for automated classification of rodent social behaviors using machine learning, offering high accuracy and ease of use without requiring specialized hardware or programming knowledge.

Construction of Nanobody Library in Mammalian Cells by Linear-double-stranded DNA Based AND Gate Genetic Circuit

The paper constructs a nanobody library in mammalian cells using an ldsDNA-based AND gate genetic circuit, generating 22,173 unique sequences.

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.