Author

M.-L. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Evans-Molina· 2 shared C. Speake· 2 shared E. A. James· 2 shared J. Kanyo· 2 shared K. C. Herold· 2 shared M. J. Mamula· 2 shared R. Gee· 2 shared T. Lam· 2 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPhysiology

C. Evans-Molina

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Author profile →

3 papers

Recent·Most cited

A discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

F. Syed, D. Singhal, K. Raedschelders, P. Krishnan, R. N. Bone, M. R. McLaughlin, J. E. Van Eyk, R. G. Mirmira, M.-L. Yang, M. J. Mamula, H. Wu, X. Liu, C. Evans-Molina

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

bioRxiv · Dec 22, 2021 · PreprintPhysiology

Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity

M.-L. Yang, S. Connolly, R. Gee, T. Lam, J. Kanyo, S. G. Clarke, C. F. Clarke, E. A. James, C. Speake, C. Evans-Molina, L. Wen, K. C. Herold, M. Mamula

The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.

bioRxiv · Jun 15, 2021 · PreprintImmunology

Citrullination of glucokinase linked to autoimmune diabetes

M.-L. Yang, S. Horstman, R. Gee, P. Guyer, T. Lam, J. Kanyo, A. Perdigoto, C. Speake, C. J. Greenbaum, L. Overbergh, R. Kibbey, K. C. Herold, E. A. James, M. J. Mamula

This study identifies citrullination of glucokinase as an inflammatory-driven PTM that triggers autoimmunity and impairs glucose metabolism in Type 1 diabetes.

bioRxiv · Apr 28, 2021Immunology