Author

A. L. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. M. Brown· 3 shared A. J. Lusis· 2 shared B. Willard· 2 shared C. Neumann· 2 shared D. S. Allende· 2 shared E. Akcay· 2 shared J. C. Garcia-Garcia· 2 shared J. T. Anderson· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

J. M. Brown

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis

W. Massey, V. Varadharajan, R. Banerjee, A. L. Brown, A. J. Horak, R. C. Hohe, E. R. Chan, C. Pan, R. Zhang, D. S. Allende, A. J. Lusis, J. M. Brown

This study shows that MBOAT7 in adipocytes regulates PI homeostasis and contributes to hyperinsulinemia and systemic insulin resistance in mice.

bioRxiv · May 19, 2022 · PreprintBiochemistry

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

R. N. Helsley, T. Miyata, A. Kadam, V. Venkateshwari, N. Sangwan, E. C. Huang, R. Banerjee, A. L. Brown, K. K. Fung, W. Massey, C. Neumann, O. Danny, L. J. Osborn, R. C. Schugar, M. R. McMullen, , J. M. Brown

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

bioRxiv · Dec 31, 2021Biochemistry

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

R. C. Schugar, C. M. Gliniak, R. N. Helsley, A. L. Brown, A. Burrows, C. Finney, K. K. Fung, F. M. Allen, D. Ferguson, A. D. Gromovsky, C. Neumann, A. McMillan, J. A. Buffa, J. T. Anderson, M. Mehrabian, , J. M. Brown

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

bioRxiv · Dec 4, 2020Physiology

Evolution of symbiont transmission in conditional mutualisms in spatially and temporally variable environments

A. L. Brown, E. Akcay

This study models the evolution of symbiont transmission modes in conditional mutualisms under environmental variation, finding that horizontal transmission can contain symbionts in beneficial environments while vertical transmission can do so when environmental states are synchronized.

bioRxiv · May 5, 2020 · PreprintEvolutionary Biology

Evolution of transmission mode in conditional mutualisms with spatial variation in symbiont quality

A. L. Brown, E. Akcay

The paper models how spatially conditional mutualisms influence host transmission strategies, finding that symbiont effects on lifespan drive host evolution of horizontal transmission.

bioRxiv · May 4, 2018Evolutionary Biology