T. Miyata

Cryo-EM of cytoskeletal 'fibril' protein involved in Spiroplasma swimming

The paper determines the structure of a fibril protein in Spiroplasma using cryo-EM, revealing its helical organization and interactions with MreB filaments.

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection

This study develops a biparatopic anti-TNFR2 antagonist that binds in a 1:1 ratio, preventing unwanted signal transduction and suppressing regulatory T cell proliferation.

Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25 by silkworm, Bombyx mori, and its biochemical analysis.

This study expresses and purifies recombinant Pvs25 from silkworms, demonstrating its potential as a malaria transmission-blocking vaccine candidate with high immunogenicity.

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5

This study shows that inhibiting PAI-1 with TM5614 reduces PM2.5-induced cardiopulmonary and vascular damage in both in vivo and in vitro models.

Isolation and structure of the fibril protein, a major component of the internal ribbon for Spiroplasma swimming

This study isolates and characterizes the fibril protein, a key component of the helical ribbon in Spiroplasma, revealing its structural organization and role in cell helicity.

Possible changes in fidelity of DNA polymerase δ in ancestral mammals

The paper investigates amino acid substitutions in DNA polymerase δ in ancestral mammals and explores their potential impact on mutation rates.

Native structure of flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries

The paper determines the native structure of the bacterial flagellar MS ring, revealing it is 34-fold symmetric with 23-fold and 11-fold subsymmetries in its inner and middle regions.

Structure of the native supercoiled flagellar hook as a universal joint

This paper reports the native supercoiled structure of the bacterial flagellar hook at 3.1 Å resolution using cryoEM single particle analysis, revealing its dynamic universal joint mechanism.