Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP
Y. Imaizumi, K. Takanuki, T. Miyake, M. Takemoto, K. Hirata, M. Hirose, R. Oi, T. Kobayashi, K. Miyoshi, R. Aruga, T. Yokoyama, S. Katagiri, H. Matsuura, K. Iwasaki, T. Kato, , T. Nogi
This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.
bioRxiv · Jan 31, 2022Biochemistry