M. Hirose

Structural analysis of S-ring composed of FliFG fusion proteins in marine Vibrio polar flagellar motors

The paper reports the near-atomic structure of the S-ring from Vibrio alginolyticus flagellar motor using cryo-EM, revealing structural differences compared to Salmonella.

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

Slitflow: a Python framework for single-molecule dynamics and localization analysis

Slitflow is a Python framework for single-molecule dynamics and localization analysis, offering a flexible workflow for image processing, dynamics analysis, and figure creation.

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

A comprehensive analysis of the gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs

This study analyzes gut and skin microbiota in Shiba Inu dogs with canine atopic dermatitis and evaluates the impact of JAK inhibitor treatment on microbiota composition.

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution

This study presents the structure of Odinarchaeota tubulin and shows it forms tubules similar to FtsZ, suggesting it is an evolutionary intermediate between prokaryotic and eukaryotic microtubule-forming proteins.

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines

The paper shows the Delta variant can escape NTD antibodies and gain infectivity when specific RBD mutations are present, suggesting the need for updated vaccines.

Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion

The paper improves epitope tag insertion for 3D structure determination by using PA14 tags, which reduce structural changes in targets compared to PA12 tags.