Author

M. Takemoto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

O. Nureki· 3 shared K. Hirata· 2 shared R. Ishitani· 2 shared Y. Lee· 2 shared A. Minoda· 1 shared A. Suto· 1 shared C. Betsholtz· 1 shared H. Matsuura· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

O. Nureki

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

J. Shoda, S. Tanaka, K. Etori, K. Hattori, T. Kasuya, K. Ikeda, Y. Maezawa, A. Suto, K. Suzuki, J. Nakamura, Y. Maezawa, M. Takemoto, C. Betsholtz, K. Yokote, S. Ohtori, H. Nakajima

This study identifies Semaphorin 3G as a factor that worsens joint inflammation by promoting macrophage accumulation and proliferation in RA synovium.

bioRxiv · Feb 12, 2022Pathology

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

Y. Imaizumi, K. Takanuki, T. Miyake, M. Takemoto, K. Hirata, M. Hirose, R. Oi, T. Kobayashi, K. Miyoshi, R. Aruga, T. Yokoyama, S. Katagiri, H. Matsuura, K. Iwasaki, T. Kato, , T. Nogi

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

bioRxiv · Jan 31, 2022Biochemistry

Free energy landscape for the entire transport cycle of triose-phosphate/phosphate translocator

M. Takemoto, Y. Lee, R. Ishitani, O. Nureki

This study uses molecular dynamics simulations to reveal the free energy landscape and mechanism of the triose-phosphate/phosphate translocator's transport cycle.

bioRxiv · Oct 20, 2017Biophysics

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity

Y. Lee, T. Nishizawa, M. Takemoto, K. Kumazaki, K. Yamashita, K. Hirata, A. Minoda, S. Nagatoishi, K. Tsumoto, R. Ishitani, O. Nureki

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.

bioRxiv · Aug 18, 2017Biochemistry