A. C. Puhl

Discovery of a Novel Inhibitor for Chikungunya Virus

This study identifies 3-methyltoxoflavin as an inhibitor of Chikungunya virus with EC50 200 nM and activity against yellow fever virus.

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

This study tests FDA-approved kinase inhibitors against SARS-CoV-2 in vitro and in vivo, finding that vandetanib reduces inflammatory cytokines and mitigates lung inflammation in infected mice without reducing viral load.

Pyronaridine Protects Against SARS-CoV-2 in Mouse

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

This study evaluates the in vitro antiviral activity of three Ebola and Marburg virus inhibitors against SARS-CoV-2 and explores their potential mechanisms of action.

Machine Learning Models Identify Inhibitors of SARS-CoV-2

The paper uses machine learning to predict SARS-CoV-2 inhibitors from FDA-approved compounds, identifying CPI1062 and CPI1155 as potential antiviral drugs.