T. R. Lane

Development and characterization of pFluor50, a fluorogenic-based kinetic assay system for high-throughput inhibition screening and characterization of time-dependent inhibition and inhibition type for six human CYPs

The paper develops pFluor50, a fluorogenic kinetic assay system for high-throughput inhibition screening of six human CYPs, determining KM, Vmax, and inhibition types.

Strain dependent structural effects and in vivo efficacy of enterovirus-D68 inhibitors

This study develops a potent EV-D68 inhibitor, 11526092, showing improved in vitro potency and in vivo efficacy compared to pleconaril, with strain-dependent structural effects observed via cryo-EM.

Pyronaridine Protects Against SARS-CoV-2 in Mouse

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

This study evaluates the in vitro antiviral activity of three Ebola and Marburg virus inhibitors against SARS-CoV-2 and explores their potential mechanisms of action.

Machine Learning Models Identify Inhibitors of SARS-CoV-2

The paper uses machine learning to predict SARS-CoV-2 inhibitors from FDA-approved compounds, identifying CPI1062 and CPI1155 as potential antiviral drugs.

Towards the Target: Tilorone, Quinacrine and Pyronaridine Bind to Ebola Virus Glycoprotein

The paper identifies three drugs, tilorone, quinacrine, and pyronaridine, as potential Ebola virus inhibitors through computational docking and experimental validation, showing higher potency than toremifene.

Repurposing Pyramax for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate

The paper evaluates the antiviral efficacy of Pyramax(R), a malaria treatment, against Ebola virus and finds its components act additively to inhibit infection.

Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig

This paper evaluates pyronaridine tetraphosphate's efficacy against Ebola and Marburg viruses in guinea pigs, showing 40% survival and suggesting its potential for antiviral repurposing.