Author

G. F. Gomes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. T. Fabro· 3 shared F. P. Veras· 3 shared S. S. Batah· 3 shared A. C. Puhl· 2 shared F. Cunha· 2 shared J. C. Alves-Filho· 2 shared S. Damasceno· 2 shared S. Ekins· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. T. Fabro

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3 papers

Recent·Most cited

Targeting Neutrophils Extracellular Traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

F. P. Veras, G. F. Gomes, B. M. Silva, C. Almeida, C. M. Silva, A. H. Schneider, E. S. Corneo, C. S. Bonilha, S. S. Batah, R. P. Martins, E. Arruda, A. T. Fabro, J. C. A. Alves-Filho, T. M. Cunha, F. Q. Cunha

This study shows that DNase I treatment reduces NETs and organ injury in a COVID-19 mouse model.

bioRxiv · Apr 27, 2022Pharmacology & Toxicology

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

A. C. Puhl, G. F. Gomes, S. Damasceno, E. J. Fritch, J. A. Levi, N. J. Johnson, F. Scholle, L. Premkumar, B. L. Hurst, F. LeeMontiel, F. P. Veras, S. S. Batah, A. T. Fabro, N. J. Moorman, B. Yount, , S. Ekins

This study tests FDA-approved kinase inhibitors against SARS-CoV-2 in vitro and in vivo, finding that vandetanib reduces inflammatory cytokines and mitigates lung inflammation in infected mice without reducing viral load.

bioRxiv · Dec 16, 2021 · PreprintImmunology

Pyronaridine Protects Against SARS-CoV-2 in Mouse

A. C. Puhl, G. F. Gomes, S. Damasceno, A. S. de Godoy, G. D. Noske, A. M. Nakamura, V. O. Gawrijuk, R. S. Fernandes, N. Monakhova, O. Riabova, T. R. Lane, V. Makarov, F. P. Veras, S. S. Batah, A. T. Fabro, , S. Ekins

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

bioRxiv · Sep 30, 2021 · PreprintPharmacology & Toxicology