Author

R. S. Hegde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:deep learning· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

R. J. Keenan· 2 shared A. Batiuk· 1 shared A. C. Almeida· 1 shared A. Hsu· 1 shared A. J. Cesare· 1 shared A. J. O. Lewis· 1 shared A. P. Sobinoff· 1 shared A. Wagner· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

R. J. Keenan

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Author profile →

4 papers

Recent·Most cited

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay

A. Batiuk, M. Höpfler, A. C. Almeida, D. T. En-Jie, O. Vadas, E. Vartholomaiou, R. S. Hegde, Z. Lin, I. Gasic

The paper shows soluble β-tubulins sequester TTC5 to regulate tubulin mRNA decay, with loss of sequestration leading to reduced mRNA levels and chromosome segregation defects.

bioRxiv · Apr 12, 2024Cell Biology

Structural analysis of the dynamic ribosome-translocon complex

A. J. O. Lewis, F. Zhong, R. J. Keenan, R. S. Hegde

The paper uses cryo-EM and structure prediction to analyze new configurations of the ribosome-translocon complex, revealing dynamic interactions during protein biogenesis.

bioRxiv · Dec 22, 2023Biochemistry

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

C. B. Nelson, S. Rogers, K. Roychoudhury, Y. S. Tan, C. J. Atkinson, A. P. Sobinoff, C. G. Tomlinson, A. Hsu, R. Lu, E. Dray, M. Haber, J. I. Fletcher, A. J. Cesare, R. S. Hegde, H. A. Pickett

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

bioRxiv · Oct 10, 2022Cell Biology

The architecture of EMC reveals a path for membrane protein insertion

J. P. O'Donnell, B. P. Phillips, Y. Yagita, S. Juszkiewicz, A. Wagner, D. Malinverni, R. J. Keenan, E. A. Miller, R. S. Hegde

The paper determines the structure of the EMC complex and identifies a pathway for membrane protein insertion by analyzing its architecture and interactions.

bioRxiv · May 15, 2020Biochemistry