Author

C. B. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. J. Cesare· 2 shared H. A. Pickett· 2 shared A. Dhawan· 1 shared A. Gilman· 1 shared A. Gonzalez Manjon· 1 shared A. Hsu· 1 shared A. K. L. Leung· 1 shared A. Korotkov· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. J. Cesare

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Homologous recombination promotes mitotic death to suppress the innate immune response

R. Szmyd, S. Casolin, L. French, A. Gonzalez Manjon, A. Dhawan, C. B. Nelson, L. Cavalli, S. G. Page, E. Hau, H. A. Pickett, H. E. Gee, A. J. Cesare

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

bioRxiv · May 4, 2024 · PreprintCell Biology

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

D. Firsanov, M. Zacher, X. Tian, Y. Zhao, T. L. Sformo, G. Tombline, S. A. Biashad, A. Gilman, N. Hamilton, A. Patel, M. Straight, M. Lee, J. Y. Lu, E. Haseljic, A. Williams, , Gladyshev

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

bioRxiv · May 7, 2023 · PreprintCancer Biology

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

C. B. Nelson, S. Rogers, K. Roychoudhury, Y. S. Tan, C. J. Atkinson, A. P. Sobinoff, C. G. Tomlinson, A. Hsu, R. Lu, E. Dray, M. Haber, J. I. Fletcher, A. J. Cesare, R. S. Hegde, H. A. Pickett

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

bioRxiv · Oct 10, 2022Cell Biology