Author

R. S. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

X. Jiang· 3 shared A. L. Soung· 2 shared M. D. Cain· 2 shared S. Ai· 2 shared A. Bailey· 1 shared A. Bice· 1 shared A. Boon· 1 shared A. Creanga· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMicrobiology

X. Jiang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezualen Equine Encephalitis virus within olfactory sensory neurons

R. S. Klein, M. D. Cain, N. R. Klein, X. Jiang

This study shows that intranasal IFNα treatment suppresses VEEV replication and neuroinvasion in olfactory sensory neurons, improving survival and delaying encephalitis onset in mice.

Journal of Neuroinflammation · Jan 17, 2024Peer-reviewedImmunology

Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity

S. C. Agner, L. M. Brier, J. D. Hill, E. Y. Liu, A. Bice, R. M. Rahn, J. P. Culver, R. S. Klein

This study investigates how myeloid cell activation during ZIKV encephalitis correlates with recovery of cortical functional connectivity in mice.

bioRxiv · Jul 6, 2023 · PreprintBiophysics

Single-cell RNA transcriptome analysis reveals CXCL16/CXCR6 as maintenance factors for CNS tissue resident T cells that drive synapse elimination during viral recovery

S. Rosen, A. L. Soung, W. Yang, S. Ai, M. Kanmogne, V. A. Dave, S. Prabhakar, A. Swain, M. Artyomov, J. A. Magee, R. S. Klein

bioRxiv · Oct 8, 2021 · PreprintImmunology

Targeting interferon-{lambda} signaling promotes recovery from central nervous system autoimmunity

S. Manivasagam, J. L. Williams, L. L. Vollmer, B. Bollman, J. M. Bartleson, S. Ai, G. F. Wu, R. S. Klein

This study shows that blocking IFNL signaling reduces autoimmune inflammation in MS by impairing T cell effector function and APC activity.

bioRxiv · Aug 17, 2021Immunology

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

A. Vanderheiden, J. Thomas, A. L. Soung, M. E. Davis-Gardner, K. Floyd, F. Jin, D. A. Cowan, K. Pellegrini, A. Creanga, A. Pegu, A. Derrien-Colemyn, P.-Y. Shi, A. Grakoui, R. S. Klein, S. E. Bosinger, , M. S. Suthar

This study identifies a CCR2-dependent monocyte-derived cell mechanism that restricts SARS-CoV-2 infection and inflammation in the lungs of mice.

bioRxiv · May 3, 2021 · PreprintImmunology

A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters.

T. Bricker, T. Darling, A. Hassan, H. Harastani, A. Soung, X. Jiang, Y.-N. Dai, H. Zhao, L. Adams, M. Holtzman, A. Bailey, J. B. Case, D. Fremont, R. S. Klein, M. Diamond, A. Boon

This study compares intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine in hamsters, finding that intranasal immunization provides superior protection against infection and inflammation.

bioRxiv · Dec 2, 2020Microbiology

Encephalitic alphaviruses exploit caveolae-mediated transcytosis at the blood-brain barrier for CNS entry

R. S. Klein, H. Salimi, M. D. Cain, X. Jiang, R. Roth, W. Beatty, C. Sun, W. B. Klimstra, J. S. Hou

This study shows alphaviruses use caveolae-mediated transcytosis across the blood-brain barrier to enter the CNS, and IFN restricts this process.

bioRxiv · Oct 16, 2019 · PreprintMicrobiology