A. Grakoui

CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment

This study shows that CD4+ and CD8+ T cells are necessary to prevent SARS-CoV-2 persistence in the nasal compartment but not in the lungs.

Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease

This study shows that a western diet impairs T regulatory cell function in NAFLD, leading to chronic inflammation and fibrosis, and suggests restoring Treg function as a potential therapy.

Memory in Repetitive Protein-Protein Interaction Series -- in Memory of the Late Professor Robert M. Nerem

The paper analyzes memory effects in repetitive protein-protein interactions using experimental techniques and models, finding short- and intermediate-term memory in TCR-pMHC interactions.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection

This study shows that plasmacytoid dendritic cells recognize SARS-CoV-2, produce type I and III interferons, and reduce viral replication in infected airway epithelial cells.

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

This study identifies a CCR2-dependent monocyte-derived cell mechanism that restricts SARS-CoV-2 infection and inflammation in the lungs of mice.

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

This study shows SARS-CoV-2 infects human airway epithelial cultures, induces pro-inflammatory cytokines, and is inhibited by type I and III IFNs.