Author

J. J. Lafaille

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Bafica· 1 shared A. C. Iuga· 1 shared A. C. Kimmelman· 1 shared A. Crane· 1 shared A. Jayaprakash· 1 shared B. Sgarbi Reis· 1 shared C. Au· 1 shared C. Ng· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

A. Bafica

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

L. Wu, K. E. R. Hollinshead, Y. Hao, C. Au, L. Kroehling, C. Ng, W.-y. Lin, D. Li, H. M. Silva, J. Shin, J. J. Lafaille, R. Possemato, M. E. Pacold, T. Y. Papagiannakopoulos, A. C. Kimmelman, , D. R. Littman

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

bioRxiv · Jun 10, 2020Immunology

Multifaceted influence of pre-mitotic cytotoxicity of primed CD8 T cells on immunity and infection

D. B. Dandamudi, D. A. Blair, R. Arifa, J. J. Lafaille, M. L. Dustin, V. Mayya

This study investigates how pre-mitotic cytotoxic CD8 T cells (PMCs) influence immune responses and infection outcomes by killing antigen-bearing dendritic cells.

bioRxiv · Nov 2, 2018 · PreprintImmunology

Vasculature-associated adipose tissue macrophages dynamically adapt to inflammatory and metabolic challenges

H. Moura Silva, A. Bafica, G. F. Rodrigues-Luiz, J. Chi, P. d. A. Santos, B. Sgarbi Reis, D. Hoytema van Konijnenburg, A. Crane, R. D. N. Arifa, P. Martin, D. A. Gasparin Bueno Mendes, D. S. Mansur, V. Torres, K. Cadwell, P. Cohen, , J. J. Lafaille

The paper identifies vasculature-associated adipose tissue macrophages (VAMs) and shows how they adapt to metabolic and inflammatory challenges in epididymal white adipose tissue.

bioRxiv · May 31, 2018Immunology

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23

L. Chen, Z. He, A. C. Iuga, S. M. Filho, J. J. Faith, J. C. Clemente, M. Deshpande, A. Jayaprakash, J.-F. Colombel, J. J. Lafaille, R. Sachidanandam, G. C. Furtado, S. A. Lira

This study shows that diet modifies the microbiota and CD4+ T cell repertoire in a mouse model of IL-23-induced colitis, leading to disease flares.

bioRxiv · Feb 19, 2018Immunology