Author

J. C. Clemente

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:metagenomics· 6 Organism:mouse· 6 Research Focus:cell type annotation· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

G. J. Britton· 6 shared J. J. Faith· 6 shared A. Grinspan· 4 shared J.-F. Colombel· 4 shared E. J. Contijoch· 3 shared C. Yang· 2 shared D. Gevers· 2 shared G. Bongers· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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6 shared papersImmunology

G. J. Britton

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Author profile →

8 papers

Recent·Most cited

Tobacco Smoke Exposure is Characterized by a Distinct Nasal Rhinotype in a Pediatric Population

H. Monaco, C. Elaiho, B. Liu, T. Chan, A. Cantor, J. M. Collaco, S. McGrath-Morrow, K. Wilson, J. C. Clemente

The paper examines the impact of secondhand tobacco smoke exposure on the nasal microbiome in children, finding a distinct microbial rhinotype associated with higher cotinine levels.

bioRxiv · Mar 15, 2024 · PreprintMicrobiology

Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis

P. Bianchimano, G. J. Britton, D. Wallach, E. Smith, L. Cox, S. Liu, K. Iwanowski, H. Weiner, J. J. Faith, J. C. Clemente, S. Tankou

This study identifies gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis, finding that vancomycin treatment promotes bacteria that induce regulatory T cells and ameliorate disease.

bioRxiv · Nov 10, 2021Immunology

Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota

C. Gutzeit, E. K. Grasset, D. B. Matthews, P. J. Maglione, G. Magri, G. J. Britton, L. Tomalin, M. Pybus, S. Tejedor Vaquero, P. K. Veeramreddy, R. Tacho-Pinot, A. Martin Nalda, M. Garcia Prat, M. Martinez Gallo, R. Dieli-Crimi, , A. Cerutti

This study shows gut IgA enhances systemic IgG responses to pneumococcal vaccines by regulating antigen translocation and immune activation via the microbiota.

bioRxiv · Apr 29, 2021 · PreprintImmunology

Quantification of discrete gut bacterial strains following fecal transplantation for recurrent Clostridioides difficile infection demonstrates long-term stable engraftment in non-relapsing recipients

V. Aggarwala, I. Mogno, Z. Li, C. Yang, G. J. Britton, A. Chen-Liaw, J. Mitcham, G. Bongers, D. Gevers, J. C. Clemente, J.-F. Colombel, A. Grinspan, J. J. Faith

The paper quantifies bacterial strain engraftment after FMT for rCDI and shows long-term stability in non-relapsing recipients, linking strain presence to clinical outcomes.

bioRxiv · Sep 10, 2020 · PreprintImmunology

Defined microbiota transplant restores Th17/RORtγ+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

G. J. Britton, E. J. Contijoch, M. P. Spindler, V. Aggarwala, G. Bongers, L. San Mateo, A. Baltus, A. Das, D. Gevers, T. J. Borody, N. O. Kaakoush, M. A. Kamm, H. Mitchell, S. Paramsothy, J. C. Clemente, , J. J. Faith

The paper shows that transplanting healthy microbiota into mice with IBD microbiotas restores Th17/RORγt+ regulatory T cell balance by reducing pathogenic strains.

bioRxiv · Nov 16, 2019Immunology

Gut microbiota density influences host physiology and is shaped by host and microbial factors

E. J. Contijoch, G. J. Britton, C. Yang, I. Mogno, Z. Li, R. Ng, S. R. Llewellyn, S. Hira, C. Johnson, K. M. Rabinowitz, R. Barkan, I. Dotan, R. P. Hirten, S.-C. Fu, Y. Luo, , C

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

bioRxiv · Jul 12, 2018Microbiology

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23

L. Chen, Z. He, A. C. Iuga, S. M. Filho, J. J. Faith, J. C. Clemente, M. Deshpande, A. Jayaprakash, J.-F. Colombel, J. J. Lafaille, R. Sachidanandam, G. C. Furtado, S. A. Lira

This study shows that diet modifies the microbiota and CD4+ T cell repertoire in a mouse model of IL-23-induced colitis, leading to disease flares.

bioRxiv · Feb 19, 2018Immunology

Deciphering the combinatorial influence of diet and the microbiota on experimental colitis

S. R. Llewellyn, G. J. Britton, E. J. Contijoch, A. Mortha, J.-F. Colombel, A. Grinspan, J. C. Clemente, M. Merad, J. J. Faith

This study investigates how diet and microbiota interact to influence colitis severity in mice, finding that protein and psyllium fiber have significant effects through microbiota-dependent and independent mechanisms.

bioRxiv · Mar 17, 2017Microbiology