Author

R. Somech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Arbiv· 1 shared A. Drori· 1 shared A. Hendel· 1 shared A. Lev· 1 shared A. Nagler· 1 shared A. Saragovi· 1 shared A. Swisa· 1 shared C. Schmidl· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

A. Arbiv

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Multiplex HDR for Disease and Correction Modeling of SCID by CRISPR Genome Editing in Human HSPCs

O. Iancu, D. Allen, O. Knop, Y. Zehavi, D. Breier, A. Arbiv, A. Lev, Y. N. Lee, K. Beider, A. Nagler, R. Somech, A. Hendel

This paper models SCID and tests gene correction in human HSPCs using CRISPR-Cas9 and multiplexed HDR, showing successful T-cell development from corrected cells.

bioRxiv · Oct 7, 2022Bioengineering

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

A. Saragovi, X. Zheng, I. Abramovich, L. Cohen-Daniel, L. Zhuoning, H. Raifer, I. Omar, A. Swisa, M. Kuchersky, A. Drori, F. Marini, O. Toker, R. Somech, C. Schmidl, R. C. Hendrickson, , M. Berger

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

bioRxiv · Aug 16, 2022 · PreprintImmunology