Author

A. Saragovi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. Gottlieb· 3 shared M. Berger· 3 shared I. Abramovich· 2 shared I. Omar· 2 shared M. Kuchersky· 2 shared O. Toker· 2 shared A. Drori· 1 shared A. Swisa· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

E. Gottlieb

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

A. Saragovi, X. Zheng, I. Abramovich, L. Cohen-Daniel, L. Zhuoning, H. Raifer, I. Omar, A. Swisa, M. Kuchersky, A. Drori, F. Marini, O. Toker, R. Somech, C. Schmidl, R. C. Hendrickson, , M. Berger

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

bioRxiv · Aug 16, 2022 · PreprintImmunology

Deep learning methods for designing proteins scaffolding functional sites

J. Wang, S. Lisanza, D. Juergens, D. Tischer, I. Anishchenko, M. Baek, J. L. Watson, J.-H. Chun, L. F. Milles, J. Dauparas, M. Exposit, W. Yang, A. Saragovi, S. Ovchinnikov, D. Baker

This paper introduces two deep learning methods for designing proteins with specific functional sites, showing they can generate diverse proteins with desired properties.

bioRxiv · Nov 10, 2021Biochemistry

Cellular water analysis in T cells reveals a switch from metabolic water gain to water influx

A. Saragovi, T. Zilberman, G. Yasur, K. Turjeman, I. Abramovich, M. Kuchersky, E. Gottlieb, Y. Barenholz, M. Berger

This study uses a novel method to analyze water content in T cells and finds a shift from metabolic water gain to extracellular water influx during cell growth.

bioRxiv · May 11, 2020 · PreprintBiochemistry

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

A. Saragovi, I. Abramovitch, O. Toker, E. Arbib, I. Omar, E. Gottlieb, M. Berger

This study shows that systemic hypoxia impairs CD8+ T cell responses by inhibiting mitochondrial biogenesis, which can be rescued by TCA cycle re-stimulation or brief oxygen exposure.

bioRxiv · Mar 19, 2020Immunology