Author

A. Rukavina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

G. E. Winter· 2 shared H. Imrichova· 2 shared A. Ciulli· 1 shared A. Correa-Saez· 1 shared A. D. Cowan· 1 shared A. Testa· 1 shared C. Craigon· 1 shared C. Kagiou· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. E. Winter

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2 papers

Recent·Most cited

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

M. Cigler, H. Imrichova, F. Frommelt, L. Depta, A. Rukavina, C. Kagiou, J. T. Hannich, C. Mayor-Ruiz, G. Superti-Furga, S. Sievers, L. Laraia, H. Waldmann, G. E. Winter

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

bioRxiv · Mar 15, 2023 · PreprintPharmacology & Toxicology

Targeted protein degradation via intramolecular bivalent glues

O. Hsia, M. Hinterndorfer, A. D. Cowan, K. Iso, T. Ishida, R. Sundaramoorthy, M. A. Nakasone, H. Imrichova, C. Schatz, A. Rukavina, K. Husnjak, M. Wegner, A. Correa-Saez, C. Craigon, R. Casement, , A. Ciulli

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

bioRxiv · Feb 14, 2023Biochemistry