Author

R. Xiong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:metabolomics· 2

Frequent Co-Authors

Z. Shen· 3 shared E. Fleming· 2 shared H. Lee· 2 shared J. Oh· 2 shared A. Roy· 1 shared C. Gunter· 1 shared C. Penton· 1 shared D. C. Castaneda· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMicrobiology

Z. Shen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

High-Throughput Bioprinting of the Nasal Epithelium using Patient-derived Nasal Epithelial Cells

I. D. Derman, M. Yeo, D. C. Castaneda, M. Callender, M. Horvath, Z. Mo, R. Xiong, E. Fleming, P. Chen, M. E. Peeples, K. Palucka, J. Oh, I. T. Ozbolat

This study uses 3D bioprinting to create nasal epithelium models from patient-derived cells, enabling high-throughput fabrication and recapitulating native epithelial architecture and virus infection capability.

bioRxiv · Mar 29, 2023Bioengineering

The mechanism of nicotinamide phosphoribosyltransferase whereby positive allosteric modulation elevates cellular NAD+

K. M. Ratia, Z. Shen, J. Gordon-Blake, H. Lee, M. S. Laham, I. S. Krider, N. Christie, M. S. Ackerman-Berrier, C. Penton, N. G. Knowles, S. R. Musku, J. Fu, G. R. Musku, R. Xiong, G. R. J. Thatcher

This study identifies the mechanism by which NAMPT is activated by positive allosteric modulators, revealing how this enhances NAD+ biosynthesis and regulates NAM binding.

bioRxiv · Oct 21, 2022 · PreprintBiochemistry

Do molecular fingerprints identify diverse active drugs in large-scale virtual screening? (no)

V. Venkatraman, A. Roy, D. Demekas, J. Gaiser, R. Xiong, T. Wheeler

This study evaluates the effectiveness of molecular fingerprints in identifying active drugs during virtual screening and finds they lack discriminative power between active and inactive molecules.

bioRxiv · Sep 20, 2022Pharmacology & Toxicology

Multi-omics of host-microbiome interactions in short- and long-term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

r. xiong, C. Gunter, E. Fleming, S. Vernon, L. Bateman, D. Unutmaz, J. Oh

This study uses multi-omics analyses to compare short- and long-term ME/CFS patients with healthy controls, identifying microbiome and metabolic differences and potential biomarkers.

bioRxiv · Oct 27, 2021Microbiology

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

Z. Shen, K. Ratia, L. Cooper, D. Kong, H. Lee, Y. Kwon, Y. Li, S. Alqarni, F. Huang, O. Dubrovskyi, L. Rong, G. R. Thatcher, R. XIONG

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

bioRxiv · Feb 13, 2021Microbiology

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

R. Xiong, L. Zhang, S. Li, Y. Sun, M. Ding, Y. Wang, Y. Zhao, Y. Wu, W. Shang, X. Jiang, J. Shan, Z. Shen, Y. Tong, L. Xu, Y. Chen, , K. Xu

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Protein & Cell · Aug 4, 2020Peer-reviewedMicrobiology