Author

Rachel E. Kelemen

Boston College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Abhishek ChatterjeeiD· 3 shared Delilah JeweliD· 2 shared Quan Thanh PhamiD· 2 shared Rachel L. HuangiD· 2 shared Tim van OpijneniD· 2 shared Xiaofu CaoiD· 2 shared Bharathi SundareshiD· 1 shared Jake Glicksman· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersSynthetic Biology

Abhishek ChatterjeeORCID

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3 papers

Recent·Most cited

Directed evolution of a bacterial leucyl tRNA in mammalian cells for enhanced noncanonical amino acid mutagenesis

Rachel L. Huang, Delilah Jewel, Rachel E. Kelemen, Quan Thanh Pham, Tarah J. Yared, Shu Wang, Soumya Jyoti Singha Roy, Zeyi Huang, Samantha D. Levinson, Bharathi Sundaresh, Suyen Espinoza Miranda, Tim van Opijnen, Abhishek Chatterjee

This paper improves the efficiency of noncanonical amino acid incorporation in mammalian cells by evolving tRNAEcLeu through directed evolution in mammalian cells.

ACS Synthetic Biology · Jun 21, 2024Peer-reviewedSynthetic Biology

Precise manipulation of site and stoichiometry of capsid modification enables optimization of functional adeno-associated virus conjugates

Sarah B. Erickson, Quan Thanh Pham, Xiaofu Cao, Jake Glicksman, Rachel E. Kelemen, Seyed Sadegh Shahraeini, Sebastian Bodkin, Zainab Kiyam, Abhishek Chatterjee

This study shows that precise control over the site and stoichiometry of capsid modification in AAV vectors improves retargeting efficiency and activity.

Bioconjugate Chemistry · Dec 16, 2023Peer-reviewedSynthetic Biology

Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells

Rachel E. Kelemen, Delilah Jewel, Rachel L. Huang, Zeyu Zhu, Xiaofu Cao, Muhammad Pasha, Jon S Anthony, Tim van Opijnen, Abhishek Chatterjee

This paper develops VADER, a virus-assisted directed evolution method for improving suppressor tRNAs in mammalian cells, resulting in more active and orthogonal tRNA mutants.

bioRxiv · Jan 21, 2022 · PreprintSynthetic Biology