Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Lesley-Anne Pearson, Alain‐Pierre Petit, César Mendoza-Martínez, Fiona Bellany, De Lin, Sarah Niven, Rachel Swift, Thomas Eadsforth, Paul K. Fyfe, Marilyn Paul, Vincent L. G. Postis, Xiao Hu, Victoria H. Cowling, David W. Gray
This study characterizes small molecule inhibitors of the HsRNMT-RAM complex, showing competitive binding and uncompetitive inhibition of RNA cap methylation.
Biochemical Journal · Jan 27, 2025Peer-reviewedBiochemistry