Paul K. Fyfe

This study characterizes small molecule inhibitors of the HsRNMT-RAM complex, showing competitive binding and uncompetitive inhibition of RNA cap methylation.

The paper determines the crystal structures of unloaded and cargo-loaded VSR1-Nt, revealing two cargo binding sites and a calcium-dependent mechanism for cargo binding and release.

The paper investigates how differential STAT binding to receptor phospho-Tyr motifs influences cytokine responses, showing altered dynamics in autoimmune disorders like SLE.