Author

Lesley-Anne Pearson

University of DundeeORCID 0000-0002-7854-5962Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

De LiniD· 2 shared Alain‐Pierre PetitiD· 1 shared César Mendoza-MartíneziD· 1 shared Colin Robinson· 1 shared David W. GrayiD· 1 shared Duncan E. ScottiD· 1 shared Fiona BellanyiD· 1 shared Ian Hugh GilbertiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

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2 papers

Recent·Most cited

BiochemistryBiochemical JournalPeer-reviewedJan 27, 2025

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

Lesley-Anne Pearson, Alain‐Pierre Petit, César Mendoza-Martínez…·David W. Gray

This study characterizes small molecule inhibitors of the HsRNMT-RAM complex, showing competitive binding and uncompetitive inhibition of RNA cap methylation.

8 citations

humanprotein structure

𝕏 PostBluesky

BiochemistrybioRxivPreprintJan 24, 2025

Identification of a novel false-positive mechanism in RapidFire mass spectrometry and application in drug discovery

De Lin, Lesley-Anne Pearson, Shamshad Ahmad…·Ian Hugh Gilbert

The paper identifies a novel false-positive mechanism in RapidFire mass spectrometry and develops a pipeline to detect and mitigate these false positives in drug discovery.

DOI 10.1101/2025.01.24.634670

experimental assaydrug response / drug discovery

𝕏 PostBluesky