LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription
Gary LeRoy, Ozgur Oksuz, Nicolas Descostes, Yuki Aoi, Rais A. Ganai, Havva Ortabozkoyun, Jia-Ray Yu, Chul‐Hwan Lee, James M. Stafford, Ali Shilatifard, Danny Reinberg
The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.
Science Advances · Oct 2, 2019Peer-reviewedMolecular Biology