Author

James M. Stafford

Howard Hughes Medical InstituteORCID 0000-0002-1435-6898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Chul‐Hwan LeeiD· 2 shared Danny ReinbergiD· 2 shared Gary LeRoyiD· 2 shared Jia-Ray YuiD· 2 shared Nicolas DescostesiD· 2 shared Ozgur OksuziD· 2 shared Ali ShilatifardiD· 1 shared Aram Sandaldjian ModrekiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersMolecular Biology

Chul‐Hwan LeeORCID

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3 papers

Recent·Most cited

BiochemistryStem Cell Reviews and ReportsPeer-reviewedJan 2, 2026

The zinc-finger protein POGZ associates with Polycomb repressive complex 1 to regulate bone morphogenetic protein signaling during neuronal differentiation

Jessenia Chavez, Trevor Wolf, Cynthia Lascarez-Espana…·Zhonghua Gao

This study identifies POGZ as a novel component of PRC1.6, showing it represses BMP signaling during neuronal differentiation and links to ASD.

3 citationstop 5%

Molecular BiologyScience AdvancesPeer-reviewedOct 2, 2019

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription

Gary LeRoy, Ozgur Oksuz, Nicolas Descostes…·Danny Reinberg

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

89 citations

Molecular BiologyScience AdvancesPeer-reviewedOct 5, 2018

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

James M. Stafford, Chul‐Hwan Lee, Philipp Voigt…·Danny Reinberg

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

192 citationstop 2%

humanproteomics