Bacterial targeting of host paraspeckles uncovers a new SFPQ-based regulation
Sonia Nicchi, Sonia Mondino, Christophe Rusniok, Nassim Mahtal, Bertrand D. E. Raynal, Rayen Elj, Quentin Giai Gianetto, Joaquín Dalla Rizza, Nicole Larrieux, Jessica E. Martyn, Hanno Schoeler, Sandrine Schmutz, Florian Müller, Mariette Matondo, Alejandro Buschiazzo, , Monica Rolando
This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.
bioRxiv · Jan 12, 2026 · PreprintMicrobiology