Carmen Buchrieser

The paper analyzes how water treatment affects microbial communities and opportunistic pathogens in two water sources, finding that treatment processes can enrich specific taxa despite reducing bacterial loads.

This study uses single-cell metabolomics to show that Legionella pneumophila infection induces metabolic reprogramming in human macrophages, with bacterial effectors promoting glycolytic shifts.

This study identifies RidL as a bifunctional effector that inhibits retrograde trafficking and promotes mitochondrial fragmentation by phosphorylating Drp1, aiding Legionella pneumophila's intracellular survival.

This study identifies Complex I as essential for maintaining mitochondrial membrane potential during infection with virulent bacteria, revealing distinct strategies used by Legionella and Salmonella.

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

The paper tracks metabolic dynamics in single human macrophages infected with Legionella pneumophila to predict bacterial replication with 83% accuracy using machine learning.

The paper characterizes avirulent P. aeruginosa strains lacking T3SS genes, showing they produce variable secondary metabolites despite low cytotoxicity.

This study investigates the secretion mechanism of transmembrane effector proteins by Legionella T4bSS, revealing a two-step process involving an inner membrane intermediate.

This paper shows that the Legionella pneumophila effector LegK1 suppresses RNA silencing by interacting with Argonaute proteins and activating NF-κB signaling, enhancing bacterial virulence.

The paper presents chromosome-scale genome assemblies of Acanthamoeba castellanii and shows infection-induced chromatin reorganization during Legionella pneumophila infection.

The paper identifies over 16,000 secreted proteins in Legionella species, revealing their ability to acquire eukaryotic-like genes for intracellular replication in human cells.