Christophe Rusniok

Bacterial targeting of host paraspeckles uncovers a new SFPQ-based regulation

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites

The paper characterizes avirulent P. aeruginosa strains lacking T3SS genes, showing they produce variable secondary metabolites despite low cytotoxicity.

A Legionella pneumophila effector impedes host gene silencing to promote virulence

This paper shows that the Legionella pneumophila effector LegK1 suppresses RNA silencing by interacting with Argonaute proteins and activating NF-κB signaling, enhancing bacterial virulence.

More than 16,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

The paper identifies over 16,000 secreted proteins in Legionella species, revealing their ability to acquire eukaryotic-like genes for intracellular replication in human cells.