Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Derek J. Bangs, Brian D. Hondowicz, Kathleen Abadie, Remi Savard, Madeleine A. Weiss, Triantafyllia R. Karakousi, Peter J. Skene, Amanda W. Lund, Ananda W. Goldrath, Maximilian Heeg, Marion Pepper
This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.
bioRxiv · Oct 3, 2025 · PreprintImmunology