Primary cilia promote resistance to EGFR tyrosine kinase inhibitor, osimertinib, in non-small cell lung cancer
Li Wang, Anuradha Pandit, Sk. Kayum Alam, Rhiannon Skauge, Sergio A. Gradilone, Luke H. Hoeppner
This study shows that primary cilia formation contributes to resistance to osimertinib in EGFR-mutated NSCLC by promoting sodium influx and HDAC6 inactivity, and that targeting ciliogenesis can reverse resistance.
bioRxiv · Mar 5, 2026 · PreprintCancer Biology