Sergio A. Gradilone

This study shows that primary cilia formation contributes to resistance to osimertinib in EGFR-mutated NSCLC by promoting sodium influx and HDAC6 inactivity, and that targeting ciliogenesis can reverse resistance.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

This study shows that primary cilia in cholangiocytes regulate DNA damage response and repair, with deciliated cells showing increased DNA damage and reduced survival under genotoxic stress.