POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy
Margarida Moura, João Barbosa, Inês Mendes Pinto, Nelson Leça, Sofia Cunha‐Silva, Arianna Esposito Verza, Paulo D. Pedroso, Sarah Lemaire, Joana Duro, Miguel Marques Simoes-da-Silva, André Oliveira, Ricardo Reis, Jakob Nilsson, Cláudio E. Sunkel, Andrea Musacchio, , Carlos Conde
This study shows POLO kinase phosphorylates PP187B to inhibit its interaction with MPS1, maintaining SAC activity and preventing aneuploidy during mitosis.
Current Biology · Oct 22, 2025Peer-reviewedCell Biology