Author

Margarida Moura

Universidade do PortoORCID 0000-0002-7532-323XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Organism:Drosophila· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Carlos CondeiD· 2 shared Cláudio E. SunkeliD· 2 shared Inês Mendes PintoiD· 2 shared Nelson LeçaiD· 2 shared Paulo D. PedrosoiD· 2 shared André OliveiraiD· 1 shared Andrea MusacchioiD· 1 shared Arianna Esposito Verza· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Carlos CondeORCID

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3 papers

Recent·Most cited

Chromosome condensation mechanically primes the nucleus for mitosis

Vanessa Nunes, Margarida Moura, Sara F Silva, Débora Vareiro, Nicolas Audugé, Nicolas Borghi, Jorge Gomes Goulart Ferreira

The paper shows chromosome condensation increases nuclear envelope tension, which is necessary for cyclin B1 translocation and dynein loading, enabling timely mitotic entry.

The EMBO Journal · Jun 29, 2026Peer-reviewedCell Biology

POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy

Margarida Moura, João Barbosa, Inês Mendes Pinto, Nelson Leça, Sofia Cunha‐Silva, Arianna Esposito Verza, Paulo D. Pedroso, Sarah Lemaire, Joana Duro, Miguel Marques Simoes-da-Silva, André Oliveira, Ricardo Reis, Jakob Nilsson, Cláudio E. Sunkel, Andrea Musacchio, , Carlos Conde

This study shows POLO kinase phosphorylates PP187B to inhibit its interaction with MPS1, maintaining SAC activity and preventing aneuploidy during mitosis.

Current Biology · Oct 22, 2025Peer-reviewedCell Biology

Proximity-based activation of AURORA A by MPS1 potentiates error correction

Nelson Leça, Francisca Barbosa, Sergi Rodríguez-Calado, Arianna Esposito-Verza, Margarida Moura, Paulo D. Pedroso, Inês Mendes Pinto, Elena Artes, Tanja Bange, Cláudio E. Sunkel, Marin Barišić, Thomas J. Maresca, Carlos Conde

This study identifies a proximity-based activation mechanism where MPS1 phosphorylates AURORA A kinase to enhance error correction during mitosis.

Current Biology · Jun 13, 2024Peer-reviewedCell Biology