CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias
Travis J. Fleming, Mateusz Antoszewski, Sander Lambo, Michael C. Gundry, Riccardo Piussi, Lara Wahlster, Sanjana B. Shah, Fiona E. Reed, Kevin D. Dong, João A. Paulo, Steven P. Gygi, Claudia A. Mimoso, Seth Raphael Goldman, Karen Adelman, Jennifer A. Perry, , Vijay G. Sankaran
This study identifies MECOM's role in blocking differentiation via CEBPA repression, showing that targeting this regulatory element can promote differentiation and reduce leukemia burden in AMLs.
Blood · Sep 24, 2025Peer-reviewedCancer Biology