Kevin D. Dong

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

This study identifies MECOM's role in blocking differentiation via CEBPA repression, showing that targeting this regulatory element can promote differentiation and reduce leukemia burden in AMLs.

Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation

The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.

Insights into the Absence of Lymphoma Despite Fulminant Epstein-Barr Virus Infection in Patients with XIAP Deficiency

This study investigates why XLP-2 patients, with XIAP deficiency, avoid EBV-driven lymphoma despite severe EBV infection, finding that XIAP loss impairs EBV-induced B-cell outgrowth and promotes apoptosis.

Large-scale map of RNA binding protein interactomes across the mRNA life-cycle

The paper constructs an RNA-aware RBP-centric PPI map across the mRNA life-cycle, revealing 20,359 novel interactions and showing 73% are RNA-dependent.