Author

Riley E. Irmen

University of Kentucky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

James Andy Snipes· 2 shared Shannon L. MacauleyiD· 2 shared Anish MitraiD· 1 shared Caitlin M. CarrolliD· 1 shared Daniel C. LeeiD· 1 shared David M. HoltzmaniD· 1 shared Gopal V. VelmuruganiD· 1 shared Holden C. WilliamsiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

James Andy Snipes

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2 papers

Recent·Most cited

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

Riley E. Irmen, Sierra M. Turner, James Andy Snipes, Holden C. Williams, Gopal V. Velmurugan, Jerry B. Hunt, Junyan Li, Patrick G. Sullivan, Daniel C. Lee, Lance A. Johnson, Shannon L. Macauley

This study investigates how tau pathology affects metabolism and excitatory activity in mouse models, finding that it preserves glucose tolerance and shifts metabolic flux toward glutamate synthesis.

bioRxiv · Jul 25, 2025 · PreprintNeuroscience

Acute hyper- and hypoglycemia uncouples the metabolic cooperation between glucose and lactate to disrupt sleep

Caitlin M. Carroll, Molly Stanley, Ryan V. Raut, Nicholas J. Constantino, Riley E. Irmen, Anish Mitra, James Andy Snipes, Marcus E. Raichle, David M. Holtzman, Robert W. Gould, Kenneth T. Kishida, Shannon L. Macauley

This study shows that acute hyper- and hypoglycemia disrupt the metabolic cooperation between glucose and lactate in the brain, affecting sleep-wake cycles.

bioRxiv · Sep 15, 2022 · PreprintNeuroscience