Author

Robert T. Fremeau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Alfica Sehgal· 1 shared Ali Al Abdullatif· 1 shared Alla A. SigovaiD· 1 shared Anna Rychkova· 1 shared Birkan GökbağiD· 1 shared Bryan J. MatthewsiD· 1 shared Brynn N. AkerbergiD· 1 shared Dann Huh· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenomics

Alfica Sehgal

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2 papers

Recent·Most cited

Interpretable gene networks from single-cell foundation models reveal conserved neurogenic dysfunction in Parkinson's disease

Jun Yin, Maya L. Gosztyla, Birkan Gökbağ, Anna Rychkova, Isabel V. L. Wilkinson, John St John, Vega Shah, Sarah Nickels, Jens Christian Schwamborn, Robert T. Fremeau

The paper introduces scGENet, a framework to generate interpretable gene networks from single-cell foundation models, revealing conserved neurogenic dysfunction in Parkinson's disease.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn N. Akerberg, Bryan J. Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali Al Abdullatif, Dann Huh, Linda C. Burkly, Sandra J. Engle, Iris Grossman, Alfica Sehgal, Alla A. Sigova, Robert T. Fremeau, , David A. Bumcrot

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

Scientific Reports · Jan 25, 2024Peer-reviewedGenomics