Author

Linda C. Burkly

Biogen (United States)ORCID 0000-0002-9772-5459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Agnieszka SłowikiD· 1 shared Alejandro BustamanteiD· 1 shared Alejandro Hornick· 1 shared Alessandro A. Viana Oliveira Souza· 1 shared Alfica Sehgal· 1 shared Ali Al Abdullatif· 1 shared Alla A. SigovaiD· 1 shared Alonso GutiérreziD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Agnieszka SłowikORCID

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2 papers

Recent·Most cited

Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn N. Akerberg, Bryan J. Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali Al Abdullatif, Dann Huh, Linda C. Burkly, Sandra J. Engle, Iris Grossman, Alfica Sehgal, Alla A. Sigova, Robert T. Fremeau, , David A. Bumcrot

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

Scientific Reports · Jan 25, 2024Peer-reviewedGenomics

MULTI-ANCESTRY GENETIC STUDY IN 5,876 PATIENTS IDENTIFIES AN ASSOCIATION BETWEEN EXCITOTOXIC GENES AND EARLY OUTCOMES AFTER ACUTE ISCHEMIC STROKE

Laura Ibáñez, Laura Heitsch, Caty Carrera, Fabiana H G Farias, Jorge L. Del‐Aguila, Rajat Dhar, John Budde, Kristy Bergmann, Joseph L. Bradley, Oscar Harari, Chia‐Ling Phuah, Robin Lemmens, Alessandro A. Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, , Carlos Cruchaga

This paper identifies seven genome-wide significant loci associated with early neurological instability after acute ischemic stroke, linking excitotoxic genes to poor outcomes.

Brain · Feb 24, 2022Peer-reviewedGenetic & Genomic Medicine