APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres, Se-In Lee, Jingjie Zhu, Daphne Zhu, Pearly Ye, Kendra Norman, Mingrui Zhao, Man Ying Wong, Yohannes A. Ambaw, Rodrigo Castaneda, Wei Wang, Tark Patel, Maitreyee Bhagwat, , Li Gan
The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.
bioRxiv · Apr 25, 2024 · PreprintNeuroscience