Author

Se-In Lee

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jingjie ZhuiD· 4 shared Kendra Norman· 3 shared Li GaniD· 3 shared Man Ying WongiD· 3 shared Weixi Feng· 3 shared Wenjie LuoiD· 3 shared Haiyuan YuiD· 2 shared Katie Munechika· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Jingjie ZhuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy

Yuansong Wan, Ethan Cordes, Weixi Feng, Se-In Lee, Katie Munechika, Yu Sun, Zhisong Gao, Beichen Gao, Jingjie Zhu, Man Ying Wong, Kendra Norman, Siyu Wang, hao chen, Bangyan Liu, Zhong Li, , Li Gan

This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.

bioRxiv · Aug 23, 2026 · PreprintNeuroscience

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease

Xiaomu Wei, Katie Munechika, Yu Sun, Yuansong Wan, Tianyu Xia, Yuan Hou, Wenqiang Song, Kumar Yugandhar, Yiwen Wang, Se-In Lee, Zhengdong Sha, Yadi Zhou, Weixi Feng, Jingjie Zhu, Y. S. Tang, , Haiyuan Yu

The paper develops a neuron-specific interactome map in human excitatory neurons to identify novel risk genes and pathways in Alzheimer's disease.

bioRxiv · Mar 16, 2026 · PreprintSystems Biology

cGAS inhibition delays TDP-43-driven ALS Pathogenesis

Yajing Liu, Weixi Feng, Abulimiti Aikedan, Se-In Lee, Maitreyee Bhagwat, Ravi Kumar Nagiri, Man Ying Wong, Sadaf Amin, Wenhui Qu, Jingjie Zhu, Si-Yu Wang, Pearly Ye, Kendra Norman, Guillermo Coronas‐Samano, Marta Olah, , Li Gan

This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.

bioRxiv · Feb 26, 2026 · PreprintNeuroscience

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres, Se-In Lee, Jingjie Zhu, Daphne Zhu, Pearly Ye, Kendra Norman, Mingrui Zhao, Man Ying Wong, Yohannes A. Ambaw, Rodrigo Castaneda, Wei Wang, Tark Patel, Maitreyee Bhagwat, , Li Gan

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

bioRxiv · Apr 25, 2024 · PreprintNeuroscience