Mono-ADP-ribosylation-driven immunosuppression and cross-resistance to therapy through cancer cell intrinsic and extrinsic mechanisms
Yuchen Sun, Yingying Tang, Vivek T. Singh, Ágnes Holczbauer, Raghavendra Basavaraja, Quoc Thang Bui, Jeong‐Hwa Lee, Runnan Gao, A. Cole Edwards, Wei Guo, John Alan Diehl, Yi Fan, Constantinos Koumenis, Timour Baslan, Ben Z. Stanger, , Serge Yu. Fuchs
This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.
bioRxiv · Jun 3, 2026 · PreprintCancer Biology