Wei Guo

This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

This paper develops a microengineered platform to study CAR T cell therapy in human solid tumors, showing improved trafficking and effector function, and identifying therapeutic targets and biomarkers.

This study develops DR5-targeted CAR-T cells that kill solid tumors and MDSCs, enhance CD8+ T cell activity, and show minimal toxicity in preclinical models.

This paper introduces BDEVS, a platform for high-throughput, multiplexed, and ultra-sensitive profiling of individual extracellular vesicles in plasma, demonstrating a 100x improvement in detecting EV subpopulations.