Author

Raghavendra Basavaraja

University of PennsylvaniaORCID 0000-0002-8656-2615Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Ágnes HolczbaueriD· 2 shared Ben Z. StangeriD· 2 shared Constantinos KoumenisiD· 2 shared John Alan DiehliD· 2 shared Quoc Thang BuiiD· 2 shared Serge Yu. FuchsiD· 2 shared Vladimir S. SpiegelmaniD· 2 shared Wei GuoiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Ágnes HolczbauerORCID

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2 papers

Recent·Most cited

Mono-ADP-ribosylation-driven immunosuppression and cross-resistance to therapy through cancer cell intrinsic and extrinsic mechanisms

Yuchen Sun, Yingying Tang, Vivek T. Singh, Ágnes Holczbauer, Raghavendra Basavaraja, Quoc Thang Bui, Jeong‐Hwa Lee, Runnan Gao, A. Cole Edwards, Wei Guo, John Alan Diehl, Yi Fan, Constantinos Koumenis, Timour Baslan, Ben Z. Stanger, , Serge Yu. Fuchs

This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.

bioRxiv · Jun 3, 2026 · PreprintCancer Biology

SPTBN2 promotes an immunosuppressive tumor microenvironment and cross-resistance to anti-cancer therapies

Quoc Thang Bui, Raghavendra Basavaraja, Mayura R. Dhamdhere, Ágnes Holczbauer, Luca Paruzzo, Puneeth Guruprasad, Michael Scaglione, Yingying Tang, Yu Sun, Daniel P. Beiting, Erik Nash, Hossein Fazelinia, Lynn A. Spruce, Alice Wang, Kai Tan, , Serge Yu. Fuchs

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

bioRxiv · Apr 1, 2026 · PreprintCancer Biology