The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis
Emma CB Wall, José Afonso Guerra‐Assunção, Marie Yang, Rutger Konig, Teerawit Audshasai, Alize M Proust, Rieza Aprianto, Elisa Ramos‐Sevillano, Giuseppe Ercoli, Nicola Bordin, V. S. Agostinho-Terra, Jan‐Willem Veening, David Griffith Lalloo, Brendan William Wren, Robert John Wilkinson, , Jeremy Brown
The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.
bioRxiv · Apr 30, 2024 · PreprintMicrobiology