Author

Alize M Proust

The Francis Crick InstituteORCID 0000-0003-2809-2835Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Robert John WilkinsoniD· 2 shared Aras KadiogluiD· 1 shared Brendan William WreniD· 1 shared David Griffith LallooiD· 1 shared Diederik van de BeekiD· 1 shared Elisa Ramos‐SevillanoiD· 1 shared Emma CB WalliD· 1 shared Giuseppe ErcoliiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Robert John WilkinsonORCID

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2 papers

Recent·Most cited

MicrobiologyJournal of NeuroinflammationPeer-reviewedMay 26, 2025

M. tuberculosis invades and disrupts the blood-brain barrier directly to initiate meningitis

Alize M Proust, Katalin Andrea Wilkinson, Robert John Wilkinson

This study shows M. tuberculosis can directly cross the blood-brain barrier and cause meningitis, with HIV-1 enhancing bacterial entry and BBB disruption.

6 citations

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 30, 2024

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

Emma CB Wall, José Afonso Guerra‐Assunção, Marie Yang…·Jeremy Brown

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

4 citations

humanmouse

𝕏 PostBluesky