Author

S. B. Goodman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

C. H. Contag· 4 shared C. V. Maduka· 4 shared M. M. Kuhnert· 4 shared O. M. Habeeb· 3 shared A. Tundo· 2 shared A. V. Makela· 2 shared E. Ural· 2 shared K. D. Hankenson· 2 shared

Activity by Year

2022-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

C. H. Contag

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Stereochemistry Determines Immune Cellular Responses to Polylactide Implants

C. V. Maduka, M. Alhaj, E. Ural, M. M. Kuhnert, O. M. Habeeb, A. L. Schilmiller, K. D. Hankenson, S. B. Goodman, R. Narayan, C. H. Contag

This study shows that PLA stereochemistry affects immune responses through differential metabolic changes in macrophages and fibroblasts, with stereocomplex PLA increasing proinflammatory cytokines via glycolysis.

bioRxiv · Oct 27, 2022Bioengineering

Elevated oxidative phosphorylation is critical for immune cell activation by polyethylene wear particles

C. V. Maduka, M. M. Kuhnert, O. M. Habeeb, A. Tundo, A. V. Makela, S. B. Goodman, C. H. Contag

The paper shows that elevated oxidative phosphorylation in macrophages exposed to polyethylene particles increases ROS and proinflammatory cytokines, suggesting a role in inflammation and implant failure.

bioRxiv · Oct 19, 2022Bioengineering

Glycolytic reprogramming underlies immune cell activation by polyethylene wear particles

C. V. Maduka, O. M. Habeeb, M. M. Kuhnert, M. Hakun, S. B. Goodman, C. H. Contag

The paper shows that polyethylene particles alter immune cell metabolism, leading to glycolytic reprogramming and inflammation, which can be inhibited to promote bone integration.

bioRxiv · Oct 14, 2022Bioengineering

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

C. V. Maduka, M. Alhaj, E. Ural, M. O. Habeeb, M. M. Kuhnert, K. Smith, A. V. Makela, H. Pope, S. Chen, J. M. Hix, C. L. Mallet, S.-J. Chung, M. Hakun, A. Tundo, K. R. Zinn, , C. H. Contag

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

bioRxiv · Sep 22, 2022Bioengineering