PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation
S. Baroi, P. J. Czernik, M. Khan, J. Letson, E. Crowe, A. Chougule, P. R. Griffin, C. J. Rosen, B. Lecka-Czernik
This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.
bioRxiv · Apr 4, 2024Physiology