Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition
Anusha Kamesh, Chelsie Kadgien, Naila Kuhlmann, S. Coady, Andrea Pietrantonio, Yuting Cousineau, Anouar Khayachi, Agostinho Santos, Emily P. Hurley, Jessica C. Barron, Matthew P. Parsons, Austen J. Milnerwood
This study shows that VPS35(D620N) mutation leads to increased glutamate and dopamine transmission in mice, which can be reversed by LRRK2 inhibition.
npj Parkinson s Disease · May 3, 2025Peer-reviewedNeuroscience